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Naranjo algorithm Naranjo et al. 1981 Naranjo algorithm: A method for estimating the probability of adverse drug reactions

*   1. Are there previous conclusive reports on this reaction?
*   2. Did adverse event appear after the suspected drug was given?
*   3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?
*   4. Did the adverse reaction appear when the drug was readministered?
*   5. Are there alternative causes that could have caused the reaction?
*   6. Did the reaction reappear when a placebo was given?
*   7. Was the drug detected in any body fluid in toxic concentrations?
*   8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
*   9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
* 10. Was the adverse event confirmed by any objective evidence?

Note: If you need to embed the Naranjo Scale in your EHR please check the Evidencio's version

Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-45. PMID: 7249508

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